First goddamn minute of the game and there's...that's right! A QTE!
Brilliantly, the indicator that's supposed to indicate which key I'm supposed to press is helpfully off screen. So to pass this section I had to replay this part twice - and this is, again, in the first minute of playing - and manage to catch a glimpse of that indicator to know which key to press repeatedly to make Isaac not worthless. All this In the first. fucking. minute.